For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human Upgrade™. You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance ...
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Why Oral Testosterone Is the Ultimate Upgrade for Energy, Mood and Longevity (Men AND Women) | Shalin Shah : 1279
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1:05:01Low testosterone is sabotaging your health, motivation, and longevity. Diet alone will not fix it. In this episode of The Human Upgrade, Dave Asprey sits down with Shalin Shah, CEO of Marius Pharmaceuticals, to expose the truth about testosterone decline in both men and women. They break down why testosterone is crashing worldwide, why natural fixe…
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The Deadliest Room in Your House — And How to Detox It for Better Health | Aly Cohen MD : 1278
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1:12:45Your environment is rewiring your hormones, fertility, and long-term health without your consent. In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Aly Cohen, board-certified rheumatologist, integrative medicine specialist, and environmental health educator. Together they expose how common toxins in plastics, pesticides, drinking…
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Biohacking Your Heart Health: The Life-Saving Molecule You NEED to Know | Dr. Anurag Singh : 1277
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1:04:18What if you could reverse the age of your heart...without leaving home? In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Anurag Singh, Chief Medical Officer of Timeline, to reveal groundbreaking science that targets cardiovascular aging at the cellular level. You’ll discover how mitochondrial decline drives heart failure, why po…
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How Laser Therapy Boosts Mood, Mental Clarity, and Consciousness with Dr. Brandon Crawford : 1276
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40:48What if a laser could help a child speak for the first time—or reverse an “incurable” brain condition? In this episode of The Human Upgrade, Dave Asprey talks with Dr. Brandon Crawford, a leading neurotherapist and founder of 528 Innovations, about the emerging science of laser therapy for the brain and body. You’ll learn how light—when precisely p…
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Conscious Bacteria? The Secret New Science of Cellular Intelligence | Zach Bush : 1275
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1:42:47What if mitochondria weren’t just energy engines — but conscious beings guiding your survival and evolution? In this episode, Dave Asprey sits down with Zach Bush, MD, to uncover a radical new science of cellular intelligence. Together, they reveal how your mitochondria, microbiome, and genetic memory do far more than support survival—they actively…
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The End of Cardio? Burn Fat & Boost VO₂ Max in Just 8 Minutes a Week – with REHIT | Ulrich Dempfle : 1275
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1:06:22You’ve probably heard of HIIT—but have you heard of “REHIT?” This isn’t just another workout trend...it’s a new science-backed way to train with maximum efficiency and zero wasted time. If you’re still jogging, you’re wasting hours for minimal results. In this episode of The Human Upgrade, Dave Asprey sits down with Ulrich Dempfle, German-trained e…
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The Real Reason You Still Feel Tired—Even When Your Bloodwork Looks Perfect | Dr Pompa : 1273
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1:18:47Your bloodwork looks normal. Your doctor says you’re fine. But you still feel exhausted, inflamed, anxious—or worse. In this episode, Dave Asprey talks with Dr. Daniel Pompa, a leading voice in cellular detox and root-cause healing, to expose the hidden stressors hijacking your energy, hormones, and metabolism—even when your labs say you’re healthy…
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The $500 Billion Secret: Why Top Leaders Chase Stress | Sébastien Page : 1272
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1:20:27Most people run from stress. The world’s highest performers run toward it. Sébastien Page manages over $500 billion in global assets. He’s the CIO of one of the world’s largest investment firms, and he wrote The Psychology of Leadership while living under relentless pressure. His secret? He doesn’t avoid stress—he uses it as a tool for performance,…
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Web3 & the Future of Genetics: AI, Blockchain & Data Ownership with Nillion : 1271
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1:30:03Your DNA, health data, and digital identity are encrypted, monetized, and weaponized against you. But what if there was a way to take it back… and hack the system? In this mind-expanding episode, Dave sits down with two elite hacker-founders—Michael Tiffany, CEO of Fulcra.ai, and Vishakh, founder of Monadic DNA—to explore a radical shift in the way…
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Dr. Steven Gundry: Is Fungus Secretly Running the World—and Your Gut? : 1270
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54:11If your brain feels foggy, your mood swings like a pendulum, or your cravings seem to control you—this episode will flip what you think you know about your body and your mind. Because what if your thoughts… aren’t really yours? In this mind-altering episode of The Human Upgrade, Dr. Steven Gundry reveals a startling new theory: your gut microbiome …
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Longevity Scientists Discover a Breakthrough Peptide That Reverses Hair Loss | Carolina Reis Oliveira : 1269
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59:55If your hair is thinning, shedding, or simply not what it used to be—and nothing seems to work—this episode is for you. Because what if the story you’ve been told about balding… is wrong? For decades, hair loss has felt like fate: genetic, inevitable, untouchable. But science is catching up to something deeper—something root-level. What if the real…
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Identity Hacker: How to Completely Change Your Personality at ANY Age | Olga Khazan : 1268
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1:06:13What if you could rewrite the code of your personality—on command? Not just cope with anxiety, overthinking, or social exhaustion… but delete the traits holding you back and install better ones? This episode challenges everything you’ve been told about identity. Dave dives deep into the science of personality change to reveal why your habits, moods…
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Psychedelic States On-Demand (No Substances Needed) | Dr. Patrick Porter : 1267
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29:07Your brain isn’t broken—it’s underpowered. Energy crashes, poor sleep, brain fog, and emotional reactivity don’t just happen. You’re running on low voltage, and your mind pays the price. In this episode, Dave sits down with Dr. Patrick Porter, founder of BrainTap, to reveal how to reprogram your brain using light, sound, and guided visualization—no…
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Why Gen Z Can’t Handle the Real World (and How We Can Help Them) | Jennifer Cohen : 1266
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51:24You think you’re helping your kid. You clear the path. You smooth the bumps. You make sure they never feel too sad, too bored, too uncomfortable. It feels like love. But what if it’s making them weak? In this episode, Dave Asprey sits down with bestselling author, TED speaker, and resilience expert Jennifer Cohen to reveal how today’s parenting nor…
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The Dirty Secret Behind Ozempic: How It Wrecks Your Gut (Here’s How to Fix It) | Hannah Kleinfeld : 1265
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1:13:03For decades, gut health was reduced to yogurt commercials and vague promises from probiotics that barely worked. But what if we’ve been targeting the wrong bugs, using the wrong delivery, and ignoring the true source of chronic inflammation and accelerated aging? In this thought-provoking episode, Dave sits down with Hannah Kleinfeld, a leader in m…
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Scientists Just Discovered the Essential Nutrient That DOUBLES Dolphin Lifespan—But Should YOU Take It? | Stephanie Venn-Watson : 1256
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1:18:05For nearly a century, scientists believed we had discovered ALL of the essential fatty acids the human body needs. But what if they were wrong? Stephanie Venn-Watson, a veterinary epidemiologist and longevity researcher, joins Dave to reveal a groundbreaking discovery—a newly identified essential fatty acid, C15, that may hold the key to healthier …
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This Is Your Brain on 2025: The Biohacker’s Guide to Mental Clarity & Mood | Dr. Drew Ramsey : 1263
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1:11:07You think you’re optimizing your brain—but what if the real culprit behind your brain fog, anxiety, and burnout is the modern world itself? In this episode, Columbia University psychiatrist and nutritional neuroscience pioneer Dr. Drew Ramsey joins Dave Asprey to decode the biological chaos hijacking your mind—and how to fight back. From inflammati…
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The Science of Consciousness: What’s Beyond the Brain? | Mark Gober : 1262
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1:27:52You think, you feel, you are—but what if your consciousness isn’t just in your brain? What if reality itself is shaped by something beyond the physical? In this episode, Mark Gober—author, consciousness researcher, and former Silicon Valley banker—joins Dave Asprey to challenge everything you think you know about the mind, reality, and human potent…
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The Hidden Cost of Being Too Nice: Why People-Pleasing is Silently Killing Your Success | Scott Barry Kaufman : 1261
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1:14:46You hold the door open. You say yes when you mean no. You put others first—always. It feels like the right thing to do… but is it costing you more than you realize? In this episode, Scott Barry Kaufman, Ph.D.—Columbia professor, psychologist, and author of Rise Above—joins Dave Asprey to expose the psychology of victim vs. empowerment mindsets. He …
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MDMA Therapy Without the Drugs? How Vibration Hacks Your Brain for Neuroplasticity | Dave Rabin : 1260
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58:25What do vibrations and the psychedelic experience have in common? MDMA therapy is revolutionizing mental health treatment, helping people overcome PTSD, anxiety, and emotional trauma with unprecedented success. But what if you could tap into those same powerful benefits—without taking a single drug? It turns out your brain responds to more than jus…
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Brain Hacking 101: The Science of Self-Sabotage & Mind Reprogramming | Bizzie Gold : 1259
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1:09:58Your Brain is Lying to You—Here’s How to Take Back Control Every day, your brain is running subconscious scripts—hidden mental loops that shape your decisions, habits, and even your self-worth. But what if those loops are sabotaging you? In this episode, Bizzie Gold, mind architect and creator of The Break Method, joins Dave Asprey to expose the se…
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How Learning a New Language Rewires Your Brain—Lessons from the Pirahã Tribe | Daniel Everett : 1258
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1:11:50Is the Way You Speak Limiting How You Think? For years, scientists debated how language shapes the brain, but new research reveals it goes far beyond communication. Some languages lack numbers, grammar, or even complex sentences—yet their speakers navigate reality in ways that defy expectations. In this mind-bending episode, linguist Daniel Everett…
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Your Genes AREN’T Your Fate—The NEW Science of DNA Biohacking for SuperHuman Health | Sharon Hausman-Cohen : 1257
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1:18:33For decades, we’ve been told that our DNA is a fixed blueprint—an unchangeable code that dictates our health and lifespan. But what if that’s only half the story? Sharon Hausman-Cohen, a physician, researcher, and genomics expert at IntellxxDNA, joins Dave to reveal the cutting-edge science of genetic optimization—how understanding your DNA can unl…
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How to Build New Habits and KEEP Them! BJ Fogg & James Clear : 1256
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27:39For years, we’ve been told that willpower and repetition are the keys to forming habits. But the truth is, habits don’t stick because of repetition—they stick because of emotion! In this all-time classic episode, Dave brings together two of the world’s top habit experts—BJ Fogg, PhD, and James Clear—to break down the real science of behavior change…
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Hacking Oxytocin, How to Use Rapamycin, Level Up Your At-Home Cold Plunge, Curing Asperger’s & More! AMA #1 with Dave Asprey : 1255
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55:28In this first-ever AMA episode, Dave tackles your biggest biohacking questions—straight from The Upgrade Collective! From optimizing brain power to pushing the limits of cold therapy, this episode is packed with cutting-edge hacks to supercharge your body and mind. If you’d like to have your questions answered on the next AMA, click the link below …
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